ETF Alternatives to RYOIX - Rydex Biotechnology Inv Mutual Fund

ETF Alternatives To This Mutual Fund

In the tables below, ETFdb.com presents recommended exchange traded fund (ETF) alternatives to the mutual fund RYOIX. These recommendations are powered by ETFdb's Mutual Fund to ETF Converter tool.

How ETFdb.com has selected ETF alternatives to RYOIX: The mutual fund RYOIX has been benchmarked by Rydex/SGI against an index, S&P 500 Health Care Index, in its fund prospectus. The ETF alternatives to RYOIX listed below consist of (1) ETFs which track S&P 500 Health Care Index, and (2) ETFs which track other indexes in the same ETFdb.com Category as S&P 500 Health Care Index.

ETFs Linked To S&P 500 Health Care Index

There are no ETFs linked to S&P 500 Health Care Index.

ETFs Linked To S&P 500 Health Care Index (-100%)

There are no ETFs linked to S&P 500 Health Care Index (-100%).

Health & Biotech Equities ETFs

The following table presents exchange traded funds linked to indexes in the same ETFdb.com Category as S&P 500 Health Care Index.

Symbol Symbol	ETF Name ETF Name	Assets Assets	YTD YTD	Expense Ratio Expense Ratio
BBH	VanEck Biotech ETF	$365,742	-1.70%	0.35%
IHE	iShares U.S. Pharmaceuticals ETF	$921,538	9.50%	0.38%
XBI	State Street SPDR S&P Biotech ETF	$7,860,330	5.33%	0.35%
XPH	State Street SPDR S&P Pharmaceuticals ETF	$342,673	2.04%	0.35%
IBB	iShares Biotechnology ETF	$7,819,420	-1.03%	0.44%
FBT	First Trust NYSE Arca Biotechnology Index Fund	$2,573,410	7.08%	0.55%
PJP	Invesco Pharmaceuticals ETF	$344,336	5.97%	0.57%
PPH	VanEck Pharmaceutical ETF	$929,209	2.27%	0.36%
IYH	iShares U.S. Healthcare ETF	$3,256,960	-1.30%	0.38%
XLV	State Street Health Care Select Sector SPDR ETF	$38,942,100	-0.99%	0.08%
VHT	Vanguard Health Care ETF	$16,824,100	-1.21%	0.09%
IXJ	iShares Global Healthcare ETF	$3,705,610	-2.34%	0.40%
FXH	First Trust Health Care AlphaDEX Fund	$885,613	1.98%	0.61%
PBE	Invesco Biotechnology & Genome ETF	$257,888	0.53%	0.58%
PTH	Invesco Dorsey Wright Healthcare Momentum ETF	$111,470	-1.51%	0.60%
IHF	iShares U.S. Healthcare Providers ETF	$987,049	9.18%	0.38%
IHI	iShares U.S. Medical Devices ETF	$3,077,200	-19.72%	0.38%
XHE	State Street SPDR S&P Health Care Equipment ETF	$141,609	-8.12%	0.35%
PSCH	Invesco S&P SmallCap Health Care ETF	$133,391	4.29%	0.29%
XHS	State Street SPDR S&P Health Care Services ETF	$103,718	9.07%	0.35%
FHLC	Fidelity MSCI Health Care Index ETF	$3,041,000	-1.04%	0.08%
ARKG	ARK Genomic Revolution ETF	$1,244,490	14.43%	0.75%
BBP	Virtus Biotech ETF	$76,246	5.23%	0.34%
BBC	Virtus Biotech Clinical Trials ETF	$40,810	6.07%	0.65%
SBIO	ALPS Medical Breakthroughs ETF	$147,712	-1.72%	0.50%
FTXH	First Trust Nasdaq Pharmaceuticals ETF	$35,435	6.79%	0.60%
GNOM	Global X Genomics & Biotechnology ETF	$57,860	5.11%	0.50%
IDNA	iShares Genomics Immunology and Healthcare ETF	$160,615	10.96%	0.47%
HTEC	ROBO Global Healthcare Technology and Innovation ETF	$55,705	-2.06%	0.68%
HELX	Franklin Genomic Advancements ETF	$22,640	-4.52%	0.50%
BMED	iShares Health Innovation Active ETF	$10,240	-6.76%	0.55%
AGNG	Global X Aging Population ETF	$81,486	-3.71%	0.50%
WDNA	WisdomTree BioRevolution Fund	$2,313	N/A	0.45%
IBBQ	Invesco Nasdaq Biotechnology ETF	$65,714	1.44%	0.19%
MDEV	First Trust Indxx Medical Devices ETF	$1,885	-9.99%	0.70%
PSIL	AdvisorShares Psychedelics ETF	$33,345	11.82%	1.00%
PINK	Simplify Health Care ETF	$273,354	2.20%	0.51%
GDOC	Future Health Care Equity ETF	$20,052	-6.28%	0.75%
EKG	First Trust Nasdaq Lux Digital Health Solutions ETF	$2,597	-8.66%	0.65%
IBRN	iShares Neuroscience and Healthcare ETF	$5,128	5.15%	0.47%
MEDI	Harbor Health Care ETF	$38,238	-3.37%	0.80%
RSPH	Invesco S&P 500 Equal Weight Health Care ETF	$649,379	-0.17%	0.40%
FMED	Fidelity Disruptive Medicine ETF	$39,990	-9.85%	0.50%
CANC	Tema Oncology ETF	$171,699	4.02%	0.75%
HRTS	Tema Heart & Health ETF	$52,148	-3.83%	0.75%
LFSC	F/M Emerald Life Sciences Innovation ETF	$101,000	3.43%	0.54%
DVXV	WEBs Health Care XLV Defined Volatility ETF	$613	-1.86%	0.89%
XLVI	State Street Health Care Select Sector SPDR Premium Income ETF	$14,730	1.55%	0.35%
ASD	Defiance Autism Impact ETF	$1,243	N/A	0.79%

Inverse Equities ETFs

The following table presents exchange traded funds linked to indexes in the same ETFdb.com Category as S&P 500 Health Care Index (-100%).

Symbol Symbol	ETF Name ETF Name	Assets Assets	YTD YTD	Expense Ratio Expense Ratio
SIJ	ProShares UltraShort Industrials	$6,941	-20.49%	0.95%
EFU	ProShares UltraShort MSCI EAFE	$886	-14.01%	0.95%
SZK	ProShares UltraShort Consumer Staples	$4,959	-12.42%	0.95%
DXD	ProShares UltraShort Dow30	$47,336	-10.10%	0.95%
SDS	ProShares UltraShort S&P 500	$421,537	-13.72%	0.91%
EFZ	ProShares Short MSCI EAFE	$13,134	-5.77%	0.95%
SDP	ProShares UltraShort Utilities	$4,499	-4.40%	0.95%
SDD	ProShares UltraShort SmallCap600	$1,404	-24.85%	0.95%
SMN	ProShares UltraShort Materials	$4,051	-18.32%	0.95%
SH	ProShares Short S&P500	$1,096,690	-6.17%	0.89%
DOG	ProShares Short Dow30	$97,579	-4.20%	0.95%
MZZ	ProShares UltraShort MidCap400	$2,198	-20.34%	0.95%
SBB	ProShares Short SmallCap600	$3,577	-11.90%	0.95%
SCC	ProShares UltraShort Consumer Discretionary	$6,304	6.16%	0.95%
MYY	ProShares Short S&P Mid Cap400	$2,603	-9.85%	0.95%
RWM	ProShares Short Russell2000	$125,539	-12.80%	0.95%
TWM	ProShares UltraShort Russell2000	$50,305	-26.19%	0.95%
EWV	ProShares UltraShort MSCI Japan	$5,760	-25.28%	0.95%
PSQ	ProShares Short QQQ	$571,027	-13.33%	0.95%
QID	ProShares UltraShort QQQ	$222,826	-27.01%	0.95%
RXD	ProShares UltraShort Health Care	$3,779	3.69%	0.95%
REW	ProShares UltraShort Technology	$2,480	-42.08%	0.95%
SSG	Proshares Ultrashort Semiconductors	$46,093	-55.95%	0.95%
EUM	ProShares Short MSCI Emerging Markets	$8,407	-17.71%	0.95%
SKF	ProShares UltraShort Financials	$13,016	10.84%	0.95%
DUG	ProShares UltraShort Energy	$25,290	-43.93%	0.95%
EEV	ProShares UltraShort MSCI Emerging Markets	$3,164	-35.37%	0.95%
FXP	ProShares UltraShort FTSE China 50	$6,141	20.11%	0.95%
SEF	ProShares Short Financials	$15,218	6.62%	0.95%
TZA	Direxion Daily Small Cap Bear 3X ETF	$262,211	-38.43%	0.99%
FAZ	Direxion Daily Financial Bear 3X ETF	$108,767	14.76%	1.03%
ERY	Direxion Daily Energy Bear 2X ETF	$50,268	-43.73%	0.99%
EDZ	Direxion Daily MSCI Emerging Markets Bear 3X ETF	$21,028	-50.22%	1.34%
EPV	ProShares UltraShort FTSE Europe	$14,240	-10.90%	0.95%
BZQ	ProShares UltraShort MSCI Brazil Capped	$3,281	-16.45%	0.95%
SPXU	ProShares UltraPro Short S&P500	$448,068	-21.15%	0.90%
SQQQ	ProShares UltraPro Short QQQ	$2,038,190	-39.28%	0.95%
SDOW	ProShares UltraPro Short Dow30	$178,017	-16.10%	0.95%
SMDD	ProShares UltraPro Short MidCap400	$2,033	-30.71%	0.95%
SRTY	ProShares UltraPro Short Russell2000	$72,965	-38.65%	0.95%
SOXS	Direxion Daily Semiconductor Bear 3X ETF	$2,360,810	-90.84%	1.00%
YXI	ProShares Short FTSE China 50	$4,512	11.91%	0.95%
BIS	ProShares UltraShort Nasdaq Biotechnology	$2,447	-5.17%	0.95%
DUST	Direxion Daily Gold Miners Index Bear 2X ETF	$120,398	-16.28%	0.94%
HDGE	AdvisorShares Ranger Equity Bear ETF	$65,674	4.62%	3.62%
YANG	Direxion Daily FTSE China Bear 3X ETF	$125,146	27.40%	1.03%
KOLD	ProShares UltraShort Bloomberg Natural Gas	$148,046	-33.91%	0.95%
SPXS	Direxion Daily S&P 500 Bear 3X ETF	$387,936	-21.11%	1.04%
JDST	Direxion Daily Junior Gold Miners Index Bear 2X ETF	$42,948	-19.27%	0.92%
LABD	Direxion Daily S&P Biotech Bear 3X ETF	$75,473	-28.29%	1.07%
DRIP	Direxion Daily S&P Oil & Gas Exp. & Prod. Bear 2X ETF	$163,222	-48.81%	1.01%
SPDN	Direxion Daily S&P 500 Bear 1X ETF	$220,022	-5.89%	0.48%
OILD	MicroSectors Oil & Gas Exp. & Prod. -3x Inverse Leveraged ETN	$42,133	-60.13%	0.95%
WTID	MicroSectors Energy 3X Inverse Leveraged ETNs	$14,056	-60.94%	0.95%
EMTY	ProShares Decline of the Retail Store ETF	$3,094	1.43%	0.65%
FNGD	MicroSectors FANG+™ Index -3X Inverse Leveraged ETN	$56,993	-31.27%	0.95%
DWSH	AdvisorShares Dorsey Wright Short ETF	$11,068	-0.08%	6.22%
BNKD	MicroSectors U.S. Big Banks -3 Inverse Leveraged ETN	$1,197	-25.79%	2.60%
NRGD	MicroSectors U.S. Big Oil -3 Inverse Leveraged ETN	$26,084	-68.98%	2.60%
HIBS	Direxion Daily S&P 500 High Beta Bear 3X ETF	$19,966	-55.42%	1.06%
WEBS	Direxion Daily Dow Jones Internet Bear 3X ETF	$8,145	-8.19%	1.07%
GDXD	MicroSectors Gold Miners -3X Inverse Leveraged ETNs	$126,075	-40.70%	0.95%
BERZ	MicroSectors Solactive FANG & Innovation -3X Inverse Leveraged ETN	$8,504	-59.88%	0.95%
SARK	Tradr 1X Short Innovation Daily ETF	$57,039	-4.63%	1.00%
FLYD	MicroSectors Travel -3x Inverse Leveraged ETN	$5,530	-9.05%	0.95%
NVDS	Tradr 1.5X Short NVDA Daily ETF	$18,992	-22.96%	1.15%
TSLQ	Tradr 2X Short TSLA Daily ETF New Oct 2025	$154,176	1.43%	1.17%
AAPD	Direxion Daily AAPL Bear 1X ETF	$19,896	-9.78%	0.96%
TSLI	ProShares Ultra TSLA ETF	$5,716	-57.25%	0.95%
TSLS	Direxion Daily TSLA Bear 1X ETF	$59,477	6.22%	0.95%
AMZD	Direxion Daily AMZN Bear 1X ETF	$3,937	-7.12%	1.02%
GGLS	Direxion Daily GOOGL Bear 1X ETF	$9,392	-15.47%	1.02%
MSFD	Direxion Daily MSFT Bear 1X ETF	$8,748	14.57%	1.02%
JETD	MAX Airlines -3X Inverse Leveraged ETNs	$4,974	-29.61%	0.95%
CARD	MAX Auto Industry -3x Inverse Leveraged ETN	$1,659	-2.23%	0.95%
NVDD	Direxion Daily NVDA Bear 1X ETF	$20,917	-13.35%	1.01%
NVDQ	T-Rex 2X Inverse NVIDIA Daily Target ETF	$25,298	-33.33%	1.05%
SKRE	Tuttle Capital Daily 2X Inverse Regional Banks ETF	$7,062	-20.45%	0.75%
MSTZ	T-Rex 2X Inverse MSTR Daily Target ETF	$135,767	-48.72%	1.05%