Health & Biotech Equities ETFs invest in companies involved in the healthcare and biotechnology industries. These ETFs feature exposure to several sub-sectors including healthcare providers, healthcare services, medical devices, and pharmaceuticals.
| AUM ($,B) | # Of Funds | Average ER % | Average 1YR Return | |
|---|---|---|---|---|
| State Street | 47.75 | 6 | 0.31% | 22.01% |
| BlackRock, Inc. | 19.86 | 9 | 0.43% | 23.13% |
| Vanguard | 16.80 | 1 | 0.09% | 17.86% |
| First Trust | 3.53 | 5 | 0.62% | 17.27% |
| Fidelity | 3.03 | 1 | 0.08% | 17.92% |
| Invesco | 1.56 | 6 | 0.44% | 27.66% |
| ARK Invest LLC | 1.37 | 1 | 0.75% | 50.09% |
| VanEck | 1.25 | 2 | 0.36% | 23.52% |
| Simplify | 0.28 | 1 | 0.51% | 32.62% |
| Tema Global Ltd. | 0.18 | 1 | 0.75% | 46.62% |
| SS&C Technologies Holdings, Inc. | 0.15 | 1 | 0.50% | 62.88% |
| Mirae Asset Global Investments Co., Ltd. | 0.14 | 2 | 0.50% | 31.99% |
| Virtus Investment Partners | 0.12 | 2 | 0.50% | 76.75% |
| Exchange Traded Concepts | 0.06 | 1 | 0.68% | 26.89% |
| Dawn Global Topco Ltd. | 0.05 | 1 | 0.75% | 22.39% |
| Harbor | 0.04 | 1 | 0.80% | 18.66% |
| AdvisorShares | 0.04 | 1 | 1.00% | 54.13% |
| Franklin Templeton | 0.02 | 1 | 0.50% | 31.31% |
| Goldman Sachs | 0.02 | 1 | 0.75% | 6.77% |
| WisdomTree | 0.00 | 1 | 0.45% | 0.00% |
| Defiance Group Holdings LLC | 0.00 | 1 | 0.79% | 0.00% |
| WEBs Investments, Inc. | 0.00 | 1 | 0.89% | 0.00% |
This is a list of all US-traded ETFs that are currently included in the Health & Biotech Equities ETF Database Category by the ETF Database staff. Each ETF is placed in a single “best fit” ETF Database Category; if you want to browse ETFs with more flexible selection criteria, visit our screener. To see more information of the Health & Biotech Equities ETFs, click on one of the tabs above.
* Assets in thousands of U.S. Dollars. Assets and Average Volume as of 2026-06-06 01:01:10 -0400
The following table displays sortable historical return data for all ETFs currently included in the Health & Biotech Equities ETF Database Category. For information on dividends, expenses, or technical indicators, click on one of the tabs above.
The table below includes fund flow data for all U.S. listed Health & Biotech Equities ETFs. Total fund flow is the capital inflow into an ETF minus the capital outflow from the ETF for a particular time period.
Fund Flows in millions of U.S. Dollars.
The following table displays sortable expense ratio and commission free trading information for all ETFs currently included in the Health & Biotech Equities ETF Database Category.
The following table includes ESG Scores and other descriptive information for all Health & Biotech Equities ETFs listed on U.S. exchanges that are currently tracked by ETF Database. Easily browse and evaluate ETFs by visiting our ESG Investing themes section and find ETFs that map to various environmental, social, governance and morality themes.
The following table includes sortable dividend information on all ETFs in the Health & Biotech Equities ETF Database Category, including yield, dividend date, and beta.
The following table includes basic holdings information for each ETF in the Health & Biotech Equities, including number of holdings and percentage of assets included in the top ten holdings. To see more detailed holdings information for any ETF, click the link in the right column.
The following table displays sortable tax data for all ETFs currently included in the Health & Biotech Equities ETF Database Category. To see information on dividends, expenses, or technicals, click on one of the other tabs above.
The following table contains sortable technical indicators for all ETFs in the Health & Biotech Equities ETF Database Category. For more detailed technical metrics on any of these ETFs, click the “View” link in the right column.
The following table contains links to detailed analysis for each ETF in the Health & Biotech Equities. To see holdings, official fact sheets, or the ETF home page, click on the links below.
The following table includes ETF Database Ratings for all ETFs in the Health & Biotech Equities. The ETF Database Ratings are transparent, quant-based scores designed to assess the relative merits of potential investments. ETFs are ranked on up to six metrics, as well as an Overall Rating. Certain metrics are available only to ETF Database Pro members; sign up for a free 14-day trial for complete access
| Symbol Symbol | ETF Name ETF Name | Total Assets* Total Assets* | YTD YTD | Avg Volume Avg Volume | Previous Closing Price Previous Closing Price | 1-Day Change 1-Day Change | 1 Week 1 Week | 4 Week 4 Week | 1 year 1 year | 3 year 3 year | 5 year 5 year | YTD FF YTD FF | 1 Week FF 1 Week FF | 4 Week FF 4 Week FF | 1 Year FF 1 Year FF | 3 Year FF 3 Year FF | 5 Year FF 5 Year FF | ETF Database Category ETF Database Category | Inception Inception | ER ER | Commission Free Commission Free | Annual Dividend Rate Annual Dividend Rate | Dividend Date Dividend Date | Dividend Dividend | Annual Dividend Yield % Annual Dividend Yield % | P/E Ratio P/E Ratio | Beta Beta | # of Holdings # of Holdings | % In Top 10 % In Top 10 | Complete Complete | ST Cap Gain Rate ST Cap Gain Rate | LT Cap Gain Rate LT Cap Gain Rate | Tax Form Tax Form | Lower Bollinger Lower Bollinger | Upper Bollinger Upper Bollinger | Support 1 Support 1 | Resistance 1 Resistance 1 | RSI RSI | Advanced Advanced | Fact Sheet Fact Sheet | ETF Holdings ETF Holdings | Chart Chart | ETF Home Page ETF Home Page | Head-To-Head Head-To-Head | Overall Rating Overall Rating | Liquidity Rating Liquidity Rating | Expenses Rating Expenses Rating | Returns Rating Returns Rating | Volatility Rating Volatility Rating | Dividend Rating Dividend Rating | Concentration Rating Concentration Rating |
ESG Score
ESG Score
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ESG Score Peer Percentile (%)
ESG Score Peer Percentile (%)
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ESG Score Global Percentile (%)
ESG Score Global Percentile (%)
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Carbon Intensity (Tons of CO2e / $M Sales)
Carbon Intensity (Tons of CO2e / $M Sales)
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SRI Exclusion Criteria (%)
SRI Exclusion Criteria (%)
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Sustainable Impact Solutions (%)
Sustainable Impact Solutions (%)
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| XLV | State Street Health Care Select Sector SPDR ETF | $38,986,100 | -0.75% | 11,675,006 | $153.01 | 0.61% | 2.37% | 6.63% | 17.00% | 7.27% | 6.32% | Health & Biotech Equities | 1998-12-16 | 0.08% | N/A | $2.51 | 2026-03-23 | $0.60 | 1.64% | 17.89 | 0.58 | 62 | 60.76% | View | 40% | 20% | 1099 | $142.66 | $152.62 | $152.39 | $154.17 | 60.39 | View | View | View | View | View | View | A | A | 6.52 | 50.47% | 48.98% | 10.38 | 0.00% | 8.88% | |||||||||||
| VHT | Vanguard Health Care ETF | $16,803,300 | -0.93% | 203,077 | $284.13 | 0.26% | 1.62% | 5.63% | 17.86% | 7.27% | 5.18% | Health & Biotech Equities | 2004-01-26 | 0.09% | Vanguard | $4.70 | 2026-03-24 | $0.99 | 1.65% | 26.80 | 0.62 | 403 | 50.49% | View | 40% | 20% | 1099 | $267.08 | $284.17 | $282.96 | $286.32 | 59.24 | View | View | View | View | View | View | A | A | 6.31 | 36.81% | 40.55% | 13.55 | 0.01% | 10.70% | |||||||||||
| XBI | State Street SPDR S&P Biotech ETF | $8,154,560 | 5.53% | 9,038,180 | $128.67 | -3.56% | -5.87% | -4.48% | 56.42% | 14.39% | 0.41% | Health & Biotech Equities | 2006-01-31 | 0.35% | N/A | $0.44 | 2025-12-22 | $0.41 | 0.34% | 18.75 | 0.85 | 145 | 16.27% | View | 40% | 20% | 1099 | $127.12 | $137.98 | $126.79 | $131.93 | 46.37 | View | View | View | View | View | View | A+ | A | 3.7 | 3.42% | 1.55% | 39.06 | 0.00% | 16.50% | |||||||||||
| IBB | iShares Biotechnology ETF | $7,978,480 | -0.12% | 1,515,343 | $168.44 | -1.74% | -2.17% | -0.88% | 35.01% | 9.61% | 2.21% | Health & Biotech Equities | 2001-02-05 | 0.44% | N/A | $0.39 | 2026-03-17 | $0.12 | 0.23% | 23.21 | 0.72 | 244 | 45.88% | View | 40% | 20% | 1099 | $164.13 | $174.11 | $167.01 | $171.07 | 48.71 | View | View | View | View | View | View | A | B | 5.54 | 15.75% | 23.71% | 22.91 | 0.01% | 33.47% | |||||||||||
| IXJ | iShares Global Healthcare ETF | $3,691,650 | -1.82% | 174,200 | $95.63 | 0.58% | 1.20% | 4.40% | 12.90% | 5.67% | 4.77% | Health & Biotech Equities | 2001-11-13 | 0.40% | N/A | $1.36 | 2025-12-16 | $0.60 | 1.42% | 23.73 | 0.58 | 115 | 48.33% | View | 40% | 20% | 1099 | $90.89 | $95.77 | $95.22 | $96.25 | 56.46 | View | View | View | View | View | View | A | B+ | 6.89 | 73.24% | 65.06% | 11.68 | 0.59% | 11.35% | |||||||||||
| IHI | iShares U.S. Medical Devices ETF | $3,067,700 | -19.36% | 2,510,495 | $50.08 | 0.42% | 2.29% | 2.18% | -18.97% | -2.04% | -1.89% | Health & Biotech Equities | 2006-05-01 | 0.38% | N/A | $0.22 | 2026-03-17 | $0.04 | 0.44% | 28.95 | 0.83 | 49 | 75.33% | View | 40% | 20% | 1099 | $47.67 | $50.98 | $49.67 | $50.67 | 46.78 | View | View | View | View | View | View | A | A- | 6.14 | 30.74% | 35.85% | 13.08 | 0.00% | 15.57% | |||||||||||
| IYH | iShares U.S. Healthcare ETF | $3,045,480 | -1.02% | 811,654 | $64.24 | 0.41% | 1.92% | 6.32% | 16.61% | 6.54% | 5.22% | Health & Biotech Equities | 2000-06-12 | 0.38% | N/A | $0.81 | 2026-03-17 | $0.20 | 1.25% | 25.26 | 0.59 | 104 | 59.05% | View | 40% | 20% | 1099 | $60.02 | $64.18 | $63.98 | $64.74 | 59.90 | View | View | View | View | View | View | B+ | B+ | 6.43 | 43.26% | 45.07% | 12.14 | 0.00% | 11.39% | |||||||||||
| FHLC | Fidelity MSCI Health Care Index ETF | $3,033,150 | -0.81% | 186,518 | $73.44 | 0.25% | 1.65% | 5.70% | 17.92% | 7.27% | 5.17% | Health & Biotech Equities | 2013-10-21 | 0.08% | Fidelity | $1.01 | 2026-03-20 | $0.23 | 1.38% | 25.60 | 0.61 | 337 | 51.98% | View | 40% | 20% | 1099 | $69.01 | $73.47 | $73.16 | $74.00 | 59.33 | View | View | View | View | View | View | A | A+ | 6.32 | 37.76% | 40.89% | 13.51 | 0.01% | 10.78% | |||||||||||
| FBT | First Trust NYSE Arca Biotechnology Index Fund | $2,607,930 | 7.86% | 53,829 | $222.75 | -1.35% | 0.00% | 6.30% | 37.50% | 12.67% | 6.95% | Health & Biotech Equities | 2006-06-19 | 0.55% | N/A | $0.00 | 2024-12-13 | $1.17 | 0.00% | 26.69 | 0.68 | 31 | 41.32% | View | 40% | 20% | 1099 | $203.19 | $225.45 | $221.73 | $224.76 | 60.74 | View | View | View | View | View | View | B+ | B- | 5.59 | 17.46% | 24.53% | 21.94 | 0.00% | 43.28% | |||||||||||
| ARKG | ARK Genomic Revolution ETF | $1,368,100 | 15.33% | 2,648,808 | $33.41 | -7.89% | -3.55% | 9.61% | 50.09% | 0.16% | -15.98% | Health & Biotech Equities | 2014-10-31 | 0.75% | N/A | $0.00 | 2021-12-29 | $0.38 | 0.00% | 0.00 | 1.75 | 33 | 61.33% | View | 40% | 20% | 1099 | $26.61 | $36.07 | $32.26 | $35.17 | 57.89 | View | View | View | View | View | View | A | C+ | 4.95 | 10.25% | 15.68% | 20.37 | 0.00% | 3.96% | |||||||||||
| IHF | iShares U.S. Healthcare Providers ETF | $980,147 | 8.66% | 486,866 | $51.93 | 0.68% | 3.34% | 3.92% | 10.75% | 1.62% | 0.20% | Health & Biotech Equities | 2006-05-01 | 0.38% | N/A | $0.53 | 2026-03-17 | $0.14 | 1.03% | 24.10 | 0.74 | 62 | 76.45% | View | 40% | 20% | 1099 | $49.46 | $51.84 | $51.64 | $52.22 | 66.35 | View | View | View | View | View | View | A- | B+ | 6.16 | 31.69% | 36.42% | 10.66 | 0.00% | 0.42% | |||||||||||
| IHE | iShares U.S. Pharmaceuticals ETF | $919,351 | 9.62% | 83,994 | $92.69 | 0.27% | 1.06% | 6.02% | 44.23% | 18.56% | 10.59% | Health & Biotech Equities | 2006-05-01 | 0.38% | N/A | $1.49 | 2026-03-17 | $0.28 | 1.61% | 23.21 | 0.50 | 57 | 78.10% | View | 40% | 20% | 1099 | $86.41 | $93.43 | $92.24 | $93.53 | 59.53 | View | View | View | View | View | View | B | B+ | 6.05 | 27.70% | 33.75% | 28.82 | 0.00% | 16.11% | |||||||||||
| FXH | First Trust Health Care AlphaDEX Fund | $886,137 | 2.63% | 19,434 | $116.62 | -0.04% | 1.26% | 3.00% | 15.31% | 4.18% | 0.95% | Health & Biotech Equities | 2007-05-08 | 0.61% | N/A | $0.97 | 2026-03-26 | $0.19 | 0.83% | 19.08 | 0.75 | 77 | 27.92% | View | 40% | 20% | 1099 | $112.01 | $116.32 | N/A | N/A | 58.99 | View | View | View | View | View | View | B+ | C+ | 6.24 | 33.78% | 38.29% | 16.57 | 0.00% | 15.92% | |||||||||||
| PPH | VanEck Pharmaceutical ETF | $886,025 | 3.34% | 269,351 | $105.75 | 0.70% | 0.96% | 5.92% | 22.32% | 13.56% | 10.11% | Health & Biotech Equities | 2011-12-20 | 0.36% | N/A | $2.15 | 2026-04-01 | $0.84 | 2.04% | 23.67 | 0.47 | 26 | 74.28% | View | 40% | 20% | 1099 | $99.12 | $106.52 | $105.32 | $106.59 | 57.19 | View | View | View | View | View | View | A- | A- | 7.31 | 86.72% | 80.64% | 12.54 | 0.00% | 11.06% | |||||||||||
| RSPH | Invesco S&P 500 Equal Weight Health Care ETF | $642,971 | -0.10% | 108,032 | $31.76 | 0.13% | 1.79% | 3.82% | 11.76% | 4.07% | 3.05% | Health & Biotech Equities | 2006-11-01 | 0.40% | N/A | $0.22 | 2026-03-23 | $0.06 | 0.71% | 20.24 | 0.80 | 60 | 23.39% | View | 40% | 20% | 1099 | $29.99 | $31.61 | $31.62 | $32.01 | 60.00 | View | View | View | View | View | View | B | A- | 7.1 | 80.46% | 73.66% | 13.36 | 0.00% | 14.47% | |||||||||||
| BBH | VanEck Biotech ETF | $368,787 | -0.67% | 5,388 | $188.00 | -0.79% | -0.34% | 1.84% | 24.72% | 6.38% | 0.45% | Health & Biotech Equities | 2011-12-20 | 0.35% | N/A | $0.00 | 2024-12-23 | $1.25 | 0.00% | 23.64 | 0.71 | 25 | 69.05% | View | 40% | 20% | 1099 | $180.09 | $190.17 | $187.32 | $189.34 | 52.10 | View | View | View | View | View | View | B | A- | 6.57 | 55.03% | 50.91% | 12.68 | 0.00% | 43.11% | |||||||||||
| XPH | State Street SPDR S&P Pharmaceuticals ETF | $347,728 | 1.95% | 55,775 | $57.04 | -1.47% | -2.08% | -3.13% | 39.59% | 13.55% | 3.76% | Health & Biotech Equities | 2006-06-19 | 0.35% | N/A | $0.37 | 2026-03-23 | $0.06 | 0.65% | 9.87 | 0.61 | 59 | 26.85% | View | 40% | 20% | 1099 | $55.65 | $59.67 | $56.55 | $57.94 | 48.96 | View | View | View | View | View | View | A- | A- | 4.9 | 9.68% | 15.25% | 55.82 | 0.00% | 21.52% | |||||||||||
| PJP | Invesco Pharmaceuticals ETF | $343,310 | 6.30% | 22,695 | $110.79 | 0.40% | 1.06% | 4.96% | 39.79% | 14.55% | 8.32% | Health & Biotech Equities | 2005-06-23 | 0.57% | N/A | $1.06 | 2026-03-23 | $0.31 | 0.95% | 16.61 | 0.46 | 30 | 48.47% | View | 40% | 20% | 1099 | $104.35 | $111.25 | $110.40 | $111.54 | 58.95 | View | View | View | View | View | View | B | B- | 5.27 | 12.90% | 19.43% | 40.1 | 0.00% | 29.74% | |||||||||||
| PINK | Simplify Health Care ETF | $278,770 | 3.34% | 96,206 | $37.77 | -1.92% | -0.84% | 5.03% | 32.62% | 14.77% | N/A | Health & Biotech Equities | 2021-10-07 | 0.51% | N/A | $0.25 | 2026-03-26 | $0.05 | 0.66% | 0.00 | 0.74 | 53 | 56.65% | View | 40% | 20% | 1099 | $35.56 | $38.40 | $37.38 | $38.43 | 59.67 | View | View | View | View | View | View | A- | B- | 6.23 | 33.21% | 37.88% | 33.79 | 0.10% | 21.92% | |||||||||||
| PBE | Invesco Biotechnology & Genome ETF | $259,847 | 1.72% | 6,657 | $83.48 | -0.83% | -0.39% | 1.33% | 31.27% | 10.86% | 3.29% | Health & Biotech Equities | 2005-06-23 | 0.58% | N/A | $0.87 | 2026-03-23 | $0.08 | 1.04% | 18.99 | 0.72 | 32 | 45.64% | View | 40% | 20% | 1099 | $80.41 | $84.40 | N/A | N/A | 56.13 | View | View | View | View | View | View | B | B- | 5.68 | 19.92% | 26.04% | 27.71 | 0.00% | 39.22% | |||||||||||
| CANC | Tema Oncology ETF | $175,469 | 4.92% | 24,314 | $36.43 | -2.20% | -4.36% | -2.50% | 46.62% | N/A | N/A | Health & Biotech Equities | 2023-08-15 | 0.75% | N/A | $0.00 | 2024-12-11 | $0.73 | 0.00% | 0.00 | 0.72 | 58 | 43.30% | View | 40% | 20% | 1099 | $36.24 | $38.67 | $35.99 | $37.11 | 44.12 | View | View | View | View | View | View | B | B- | 4.87 | 9.49% | 15.00% | 27.81 | 0.00% | 15.83% | |||||||||||
| IDNA | iShares Genomics Immunology and Healthcare ETF | $164,641 | 11.26% | 40,003 | $29.14 | -2.74% | -2.48% | -2.48% | 42.27% | 7.04% | -8.26% | Health & Biotech Equities | 2019-06-11 | 0.47% | N/A | $0.31 | 2025-12-16 | $0.16 | 1.06% | 15.13 | 0.96 | 52 | 48.84% | View | 40% | 20% | 1099 | $28.43 | $30.40 | $28.86 | $29.67 | 47.75 | View | View | View | View | View | View | B+ | B | 5.38 | 13.47% | 21.02% | 25.4 | 4.32% | 28.08% | |||||||||||
| SBIO | ALPS Medical Breakthroughs ETF | $154,256 | -1.37% | 30,900 | $50.52 | -3.26% | -7.20% | -9.01% | 62.88% | 17.41% | 2.48% | Health & Biotech Equities | 2014-12-31 | 0.50% | N/A | $0.00 | 2024-12-19 | $1.17 | 0.00% | 0.00 | 0.76 | 84 | 34.61% | View | 40% | 20% | 1099 | $50.14 | $56.47 | $49.66 | $51.98 | 42.38 | View | View | View | View | View | View | B | B | 3.62 | 3.04% | 1.36% | 48.69 | 0.00% | 8.14% | |||||||||||
| XHE | State Street SPDR S&P Health Care Equipment ETF | $146,512 | -8.40% | 30,848 | $80.82 | -0.63% | 1.67% | 2.60% | -0.93% | -5.46% | -7.55% | Health & Biotech Equities | 2011-01-26 | 0.35% | N/A | $0.07 | 2025-12-22 | $0.02 | 0.09% | 16.32 | 0.97 | 68 | 22.46% | View | 40% | 20% | 1099 | $76.99 | $81.77 | $80.39 | $81.62 | 51.50 | View | View | View | View | View | View | B+ | A | 6.08 | 28.46% | 34.45% | 16.39 | 0.00% | 16.82% | |||||||||||
| PSCH | Invesco S&P SmallCap Health Care ETF | $134,145 | 3.95% | 16,146 | $45.80 | -0.54% | 1.51% | 0.70% | 12.15% | 1.15% | -5.68% | Health & Biotech Equities | 2010-04-07 | 0.29% | N/A | $0.00 | 2025-09-22 | $0.00 | 0.01% | 23.64 | 0.87 | 78 | 36.17% | View | 40% | 20% | 1099 | $44.18 | $45.84 | N/A | N/A | 58.37 | View | View | View | View | View | View | B- | A | 5.26 | 12.71% | 19.26% | 28.58 | 0.00% | 14.58% | |||||||||||
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